Background: VUR is the risk factor of recurrent UTI in children. It is difficult to select empirical antibiotics before culture tests are reported in recurrent UTI , In this study, we compared 1st UTI with recurrent infection, revealed organisms that cause UTI and drug resistance between each episode in UTI children with VUR. Methods: We retrospectively reviewed the medical records of children with VUR who had recurrent UTI during the period Jan. 1, 2012 to Jul. 31, 2017 at Severance Results: a total of 23 children with VUR developed recurrent UTIs. 16 patients (69%) had recurrent UTIs in 2 episodes, and 7 patients (30%) recurred in three episodes. A total 55 isolates of pathogens were collected. E. coli (34%) was most commonly isolated pathogen (Table 1). Of 23 patients with recurrent episodes, 7 children (30%) had the same pathogen in the 1st and 2nd episodes, 16 patients (70%) had different pathogen. Antimicrobial susceptibility of a total of 7 cases with the same pathogen between each episode is shown in Fig. 1. Conculusion: In recurrent UTI patients with VUR, the strains and antibiotic susceptibility results of each episode may be different. Antibiotics should be carefully selected, taking into account other risk factors and clinical features, regardless of previous culture results.